Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats
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Nephroprotective Activity of Benincasa hispida (Thunb.) Cogn. Fruit Extract against Paracetamol Induced Nephrotoxicity in Rats
Pharmacological research on the medicinal properties of phytochemicals has become mandatory to establish the claimed medicinal properties of herbs. Paracetamol (PCM) is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals. The aim of this study was to investigate nephroprotective activity of hydro-alcoholic extract of Benincas...
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In the present study, we investigated the effects of the aqueous extract of Mucuna pruriens against gentamicin (100 mg kg -1 per day for six days) induced oxidative stress and nephrotoxicity in rats. Administration of gentamicin to rats induced a marked renal failure, characterized by a significant increase in urine volume and serum creatinine and urea levels. There was a significant decr...
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Background and purpose: This study was designed to determine the protective effect of flower and leaf ethyl acetate extract of Viola odorata L. against ethanol induced chronic nephrotoxicity in male Wistar rats. Materials and methods: Ethyl acetate extracts of flower and leaf of V. odorata were prepared. Then, Total phenolic and flavonoid contents of extracts were determined. Animals were rand...
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Objective: Paraquat is a herbicide with potent toxicity in humans and animals. This study aimed to evaluate the protective effects of Origanum vulgare (O. vulgare) leaf extract on the acute nephrotoxicity and ...
متن کاملAbsence of Genotoxic and Mutagenic Effects of Zingiber zerumbet (L.) Smith (Zingiberaceae) Extract
The present study evaluated the potential genotoxicity of the ethanol extracts from the rhizome of Zingiber zerumbet (L.) Smith (EEZZR) using a standard battery of tests. Chemical analysis with liquid chromatography-tandem mass spectrometry revealed that EEZZR contained Zerumbone (200.3 ± 0.37 μg/g) and 6-gingerol (102.5 ± 0.28 μg/g). There were no increases in the number of revertant colonies ...
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ژورنال
عنوان ژورنال: Journal of Zhejiang University SCIENCE B
سال: 2012
ISSN: 1673-1581,1862-1783
DOI: 10.1631/jzus.b1100133